![]() Assignors: HARRIS, GREGORY DAVID Application granted granted Critical Publication of US5519143A publication Critical patent/US5519143A/en Assigned to DUPONT PHARMACEUTICALS COMPANY reassignment DUPONT PHARMACEUTICALS COMPANY CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). ![]() Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co Priority to US08/360,248 priority Critical patent/US5519143A/en Assigned to DUPONT PHARMACEUTICAL COMPANY, THE reassignment DUPONT PHARMACEUTICAL COMPANY, THE ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Original Assignee DuPont Merck Pharmaceutical Co Priority date (The priority date is an assumption and is not a legal conclusion. ![]() Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Harris Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Expired - Lifetime Application number US08/360,248 Inventor Gregory D. Google Patents Process for the isolation and purification of an imidazole stereoisomer from a mixture of stereoisomers by selective precipitationĭownload PDF Info Publication number US5519143A US5519143A US08/360,248 US36024894A US5519143A US 5519143 A US5519143 A US 5519143A US 36024894 A US36024894 A US 36024894A US 5519143 A US5519143 A US 5519143A Authority US United States Prior art keywords alkyl substituted phenyl acid formula Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US5519143A - Process for the isolation and purification of an imidazole stereoisomer from a mixture of stereoisomers by selective precipitation ![]() Then we’ll form the final product by a reaction.US5519143A - Process for the isolation and purification of an imidazole stereoisomer from a mixture of stereoisomers by selective precipitation If we convert the reagent to first 1) CH_3COONa, DMSO and then 2) NaOH, H_2O: Initially we’ll form as the product after the first step by mechanism. If this extra step did not happen we’d see compounds and as products instead. These products form due to an extra step in the mechanism. The primary products of the reaction are compounds and which are formed by and mechanisms. If we want this compound we’d have to start with the (pick one: cis, trans) diastereomer of the original starting material. On first inspection, compound appears incorrectly to be the major product, but it is prevented by difficulty getting into the transition state. The major product is compound by a(n) mechanism. racemic or diastereomers) is formed, select the single structure that shows the appropriate mixture (e.g. If a specific stereoisomer (e.g single enantiomer) is formed, select that isomer only. Look at the given reaction and use the letter code corresponding to each compound in the blank to indicate the expected product(s) or correct vocabulary word/phrase to complete the description.
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